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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: Nat Struct Mol Biol. 2011 Nov 27;18(12):1331–1335. doi: 10.1038/nsmb.2189

Fig. 5.

Fig. 5

Effect of Chk1 inhibitors in Myc- or Ras-driven pancreatic tumors. Representative images of γH2ax and activated caspase-3 (C3A) IHC done on pancreatic tumors obtained from (a) Ela-myc or (b) K-RasG12V-knockin mice, after 3 days of treatment with UCN-01 (i.p. 5 mg per kg). Black scale bars indicate 100 μm. (c) Quantification from the analysis presented in (a,b). (d) γH2ax, C3A and c-Myc IHC on the pancreatic tumor from an Ela-myc mouse after a 3 day treatment with UCN-01 (i.p. 5 mg per kg). A dashed black line separates the tumoral area from the neighbouring intestine. Black scale bars indicate 100 μm.