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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: Biochemistry. 2015 May 7;54(19):2931–2942. doi: 10.1021/acs.biochem.5b00299

Figure 2.

Figure 2

A) Structural model of the Fc-FcγRIIIa interaction (PDB 3AY4) the (B) Fc-FcγRIIa interaction (PDB 3RY6) and (C) the Fc:FcγRI interaction (PDB 4X4M). Fc N-glycans are shown as black stick models. D) Schematic diagram of the Fc:FcγR interaction. E) Fc Cγ2 loops serve as the FcγRIIIa (pink) binding site. The C’E loop includes N297, the site of N-glycosylation. The Fc chain A monomer (cyan) shown to emphasize the locations of the loops structures (PDB 1E4K). The interaction between chain A and FcγRIIIa occurs primarily at the site of these Fc Cγ2 loops.