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A) The neonatal Fc Receptor (FcRn, orange ribbon) binds to the Cg2/3 interface of IgG1 Fc (cyan ribbon) (PDB 1I1A). B) Key H-bond and ionic interactions formed between Fc and FcRn are responsible for the pH dependence of binding. Fc residues 245–260 were removed from this image for clarity. C) The PRYSPRY domain of TRIM21 (sand) recognizes the Cγ2/3 interface of IgG Fc (cyan, green) in a manner similar to FcRn (PDB 2IWG).
