Table 1. Demographics of tested dogs.
Age, gender, genotype, IOPs and tissue collection are presented.
| Dog Identification | Gender | Eye | Site5 | ADAMTS10-Genotype2 | Age (months) | Last IOP (mmHg) | Max IOP (mmHg) | Clinical Disease Stage (ONH atrophy)4 |
|---|---|---|---|---|---|---|---|---|
| G681 | M | OD | M/P | affected | 5.6 | 16.0 | n/a | none |
| G701 | M | OD | M/P | affected | 5.6 | 14.0 | n/a | none |
| G661 | M | OD | M/P | affected | 7.0 | 17.0 | n/a | none |
| G671 | M | OD | M/P | affected | 7.0 | 17.0 | n/a | none |
| ISA | M | OS | F | affected | 21.1 | 20.7 | 20.7 | none |
| AUR | F | OS | M/P | affected | 21.3 | 21.3 | 21.7 | mild |
| G21 | M | OD | M/P | affected | 38.4 | 17.0 | 31.4 | moderate |
| ANG | M | OD | F | affected | 60.1 | 32.3 | 45.0 | advanced |
| HAR3 | F | OD | F | affected | 67.3 | 55.0 | 65.3 | advanced |
| GRIF3 | M | OD | F | affected | 89.4 | 48.0 | 75.2 | advanced |
| FLA3 | M | OD | F | affected | 94.9 | 67.0 | 84.6 | advanced |
| FOR3 | M | OD | F | affected | 94.9 | 81.0 | 81.0 | advanced |
| FRE3 | M | OD | F | affected | 94.9 | 50.0 | 77.0 | advanced |
| AME | F | OD | F | affected | 124.9 | 23.7 | 28.7 | moderate |
| ZIG | M | OS | F | affected | 130.6 | 18.7 | 31.0 | moderate |
| G691 | M | OD | M/P | carrier | 5.6 | 16.0 | n/a | none |
| G711 | M | OD | M/P | carrier | 5.6 | 13.0 | n/a | none |
| G721 | F | OD | M/P | carrier | 5.6 | 11.0 | n/a | none |
| G731 | F | OD | M/P | carrier | 5.6 | 14.0 | n/a | none |
| G121 | M | OD | M/P | carrier | 32.6 | 15.0 | n/a | none |
| CHU | F | OD | M/P | normal | 69.1 | 10.7 | 17.0 | none |
| HER | F | OS | F | carrier | 72.1 | 12.0 | 19.7 | none |
| NAD | F | OD | F | carrier | 83.6 | 13.0 | 19.0 | none |
| LUC | F | OS | M/P | normal | 92.3 | 8.7 | n/a | none |
| BRI | F | OD | F | carrier | 113.0 | 13.0 | 17.3 | none |
1Samples also included in Palko et al. 2013[35]
2ADAMTS10-genotype: affected = homozygous for G661R missense mutation; carrier = unaffected, heterozygous for G661R missense mutation; normal = does not carry G661R missense mutation. Both carrier and normal dogs were included in the “normal” group for analysis.
3Eyes were treated with latanoprost ophthalmic solution (prostaglandin analogue) as needed to address pressure spikes >50 mmHg
4Degree of ONH atrophy according to Fig 3.
5The sites where the animal lived are indicated as F: University of Florida or M/P: Michigan State University and University of Pennsylvania (these animals were first raised at University of Pennsylvania and later transferred to Michigan State University).
Abbreviations: M, male; F, female; OD, right eye; OS, left eye; IOP, intraocular pressure; ONH, optic nerve head.