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. 2016 Jun 6;12(6):e1006088. doi: 10.1371/journal.pgen.1006088

Table 3. Transcripts that require both Msa1 and Msa2 for full repression.

gene MBF/SBF peak description msa1/WT msa2/WT msa1msa2/WT
THI44,7 thiamine synthesis; required for mt genome stability in response to DNA damage 0.18 -0.14 1.77
MAM15 Monopolin; kinetochore protein; chromosome attachment to meiotic spindle 0.16 0.06 1.75
YFL012W unknown function; null mutant increases resistance to rapamycin 0.42 0.32 1.50
FUR17 synthesizes UMP from uracil; involved in the pyrimidine salvage pathway 0.30 0.32 1.27
YLR162W unknown function; overexpression causes growth arrest and apoptosis -0.58 0.11 1.23
URA27 first two enzymatic steps in pyrimidine biosynthesis; feedback inhibited by UTP 0.38 0.12 1.23
TIR14,6 52 Cell wall protein; downregulated in acid, induced by cold shock and anaerobiosis 0.03 -0.12 1.18
FUI1 uridine permease; moves to the vacuole upon DNA replication stress 0.42 0.54 1.17
CRS5 Copper-binding metallothionein; required for wild-type copper resistance 0.54 0.56 1.17
YLR194C 5 cell wall protein; expression is upregulated in response to cell wall stress 0.56 0.29 1.01
STE3 a factor receptor; mediates pheromone response; required for mating 0.21 -0.41 0.95
RPS22B Protein component of the small (40S) ribosomal subunit 0.45 0.37 0.92
ACA1 ATF/CREB transcription factor; important for carbon source utilization 0.31 0.51 0.89
DAN14,6 Cell wall mannoprotein; expressed only under anaerobic conditions 0.25 -0.52 0.86
IRC7 Beta-lyase involved in thiol production; null mutant increases Rad52p foci -0.31 -0.47 0.84
SFG1 66 transcription factor; required for growth of pseudohyphae 0.59 -0.17 0.84
FDH1 NAD(+)-dependent formate dehydrogenase -0.35 -0.18 0.83
RPL9B Ribosomal 60S subunit protein L9B 0.30 0.04 0.81
AFT14,5 Transcription factor for iron deficiency; nuclear upon DNA replication stress 0.24 0.32 0.81
HSP314 stress, diauxic shift, and stationary phase survival; up in DNA replication stress 0.24 0.36 0.80
MEK15 Meiosis-specific protein kinase; meiotic checkpoint and recombination 0.42 0.32 0.80
ECM12 unknown function; mutants display zymolyase hypersensitivity 0.22 0.44 0.77
YKE4 Zinc transporter in the ER; null mutant leads to zinc accumulation in cytosol 0.26 0.38 0.76
SNA2 unknown function; has similarity to Pmp3p, which is involved in cation transport -0.12 0.47 0.76
YJL213W unknown function that may interact with ribosomes 0.05 -0.04 0.75
TIR34,6 65 Cell wall mannoprotein; required for anaerobic growth 0.60 0.26 0.74
SMF3 metal transporter involved in iron homeostasis; increases in DNA replication stress 0.38 0.52 0.73
DAL4 Allantoin permease; expression sensitive to nitrogen catabolite repression 0.01 0.36 0.73
TIR44,6 Cell wall mannoprotein; required for anaerobic growth; induced by cold shock 0.04 0.09 0.71
SPR285 Sporulation-specific homolog of the Cdc3/10/11/12 family of septins 0.03 0.14 0.71

Columns as reported in Table 2. Gene ontology terms are superscripted as:

4 response to stress,

5 meiotic cell cycle,

6 cell wall protein family,

7 pyrimidine biosynthesis.