Table 3. Transcripts that require both Msa1 and Msa2 for full repression.
gene | MBF/SBF | peak | description | msa1/WT | msa2/WT | msa1msa2/WT |
---|---|---|---|---|---|---|
THI44,7 | thiamine synthesis; required for mt genome stability in response to DNA damage | 0.18 | -0.14 | 1.77 | ||
MAM15 | Monopolin; kinetochore protein; chromosome attachment to meiotic spindle | 0.16 | 0.06 | 1.75 | ||
YFL012W | unknown function; null mutant increases resistance to rapamycin | 0.42 | 0.32 | 1.50 | ||
FUR17 | synthesizes UMP from uracil; involved in the pyrimidine salvage pathway | 0.30 | 0.32 | 1.27 | ||
YLR162W | unknown function; overexpression causes growth arrest and apoptosis | -0.58 | 0.11 | 1.23 | ||
URA27 | first two enzymatic steps in pyrimidine biosynthesis; feedback inhibited by UTP | 0.38 | 0.12 | 1.23 | ||
TIR14,6 | 52 | Cell wall protein; downregulated in acid, induced by cold shock and anaerobiosis | 0.03 | -0.12 | 1.18 | |
FUI1 | uridine permease; moves to the vacuole upon DNA replication stress | 0.42 | 0.54 | 1.17 | ||
CRS5 | Copper-binding metallothionein; required for wild-type copper resistance | 0.54 | 0.56 | 1.17 | ||
YLR194C | 5 | cell wall protein; expression is upregulated in response to cell wall stress | 0.56 | 0.29 | 1.01 | |
STE3 | a factor receptor; mediates pheromone response; required for mating | 0.21 | -0.41 | 0.95 | ||
RPS22B | Protein component of the small (40S) ribosomal subunit | 0.45 | 0.37 | 0.92 | ||
ACA1 | ATF/CREB transcription factor; important for carbon source utilization | 0.31 | 0.51 | 0.89 | ||
DAN14,6 | Cell wall mannoprotein; expressed only under anaerobic conditions | 0.25 | -0.52 | 0.86 | ||
IRC7 | Beta-lyase involved in thiol production; null mutant increases Rad52p foci | -0.31 | -0.47 | 0.84 | ||
SFG1 | 66 | transcription factor; required for growth of pseudohyphae | 0.59 | -0.17 | 0.84 | |
FDH1 | NAD(+)-dependent formate dehydrogenase | -0.35 | -0.18 | 0.83 | ||
RPL9B | Ribosomal 60S subunit protein L9B | 0.30 | 0.04 | 0.81 | ||
AFT14,5 | Transcription factor for iron deficiency; nuclear upon DNA replication stress | 0.24 | 0.32 | 0.81 | ||
HSP314 | stress, diauxic shift, and stationary phase survival; up in DNA replication stress | 0.24 | 0.36 | 0.80 | ||
MEK15 | Meiosis-specific protein kinase; meiotic checkpoint and recombination | 0.42 | 0.32 | 0.80 | ||
ECM12 | unknown function; mutants display zymolyase hypersensitivity | 0.22 | 0.44 | 0.77 | ||
YKE4 | Zinc transporter in the ER; null mutant leads to zinc accumulation in cytosol | 0.26 | 0.38 | 0.76 | ||
SNA2 | unknown function; has similarity to Pmp3p, which is involved in cation transport | -0.12 | 0.47 | 0.76 | ||
YJL213W | unknown function that may interact with ribosomes | 0.05 | -0.04 | 0.75 | ||
TIR34,6 | 65 | Cell wall mannoprotein; required for anaerobic growth | 0.60 | 0.26 | 0.74 | |
SMF3 | metal transporter involved in iron homeostasis; increases in DNA replication stress | 0.38 | 0.52 | 0.73 | ||
DAL4 | Allantoin permease; expression sensitive to nitrogen catabolite repression | 0.01 | 0.36 | 0.73 | ||
TIR44,6 | Cell wall mannoprotein; required for anaerobic growth; induced by cold shock | 0.04 | 0.09 | 0.71 | ||
SPR285 | Sporulation-specific homolog of the Cdc3/10/11/12 family of septins | 0.03 | 0.14 | 0.71 |
Columns as reported in Table 2. Gene ontology terms are superscripted as:
4 response to stress,
5 meiotic cell cycle,
6 cell wall protein family,
7 pyrimidine biosynthesis.