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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Biomaterials. 2016 Apr 21;97:122–132. doi: 10.1016/j.biomaterials.2016.04.017

Figure 2.

Figure 2

siPA is packaged more efficiently and stably with 50B polymer than unmodified siRNA. A) As evaluated by gel retardation assay, siPA loads fully at a lower N:P ratio than unmodified siRNA; note that the upward shift of siPA compared to siRNA also confirms PA conjugation. B–D) As evaluated by dynamic light scattering, siPA-NPs are more stable to elevated salt concentrations (approximately 25 nm smaller) than si-NPs at N:P = 10:1.