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Infusion of PF-429242 into CPMV. (A) Strategy for loading PF-429242 into CPMV. (B) Exterior (top) and interior (bottom) views of the capsid with 1 nm-sized pore at its 5-fold axis. (Figure rendered with Chimera based on coordinates from PDB file 1NY7.) (C) Retention of PF-429242 within CPMV capsid over time when dialyzed against buffer. (D) TEM images of CPMV before and after loading with PF-429242 indicate the particles remain intact and the structure unaltered.
