Table 3.
Number and percentage of patients with a successful outcome (cured or completed treatment at first recording of an outcome) stratified by potential confounders.
| Variable | Cases (n = 36) | Study controls (n = 36) | p-Value* comparing cases with study controls | Surveillance controls (n = 36) | p-Value* comparing cases with surveillance controls |
|---|---|---|---|---|---|
| Age | |||||
| < 35 years old | 20/25 (80.0%) | 8/17 (47.1%) | 0.045 | 3/8 (37.5%) | 0.036 |
| 35 years or older | 9/11 (81.8%) | 6/19 (31.6%) | 0.021 | 12/28 (42.9%) | 0.038 |
| Gender | |||||
| Males | 13/18 (72.2%) | 4/11 (36.4%) | 0.12 | 15/31 (48.4%) | 0.14 |
| Females | 16/18 (88.9%) | 10/25 (40.0%) | 0.002 | 0/5 (0.0%) | 0.006 |
| Treatment history | |||||
| New case | 13/13 (100.0%) | 8/19 (42.1%) | 0.001 | 6/13 (46.2%) | 0.005 |
| Previously treated case | 10/11 (80.9%) | 4/13 (30.8%) | 0.005 | 9/23 (39.1%) | 0.075 |
| Chronic case | 6/12 (50.0%) | 2/4 (50.0%) | >0.99 | ||
| Drug resistance profile | |||||
| MDR | 9/9 (100.0%) | 9/20 (45.0%) | 0.005 | 3/9 (33.3%) | 0.009 |
| Pre-XDR | 9/12 (75.0%) | 5/10 (50.0%) | 0.38 | 8/12 (66.7%) | >0.99 |
| XDR | 11/15 (73.3%) | 0/6 (0.0%) | 0.004 | 4/15 (26.7%) | 0.027 |
| Smear status at start of chemotherapy | |||||
| Positive | 3/5 (60.0%) | 5/18 (27.8%) | 0.30 | 2/5 (40.0%) | >0.99 |
| Negative | 26/31 (83.9%) | 9/18 (50.0%) | 0.020 | 13/31 (41.9%) | 0.001 |
| Current smoker | |||||
| Yes | 15/20 (75.0%) | 10/25 (40.0%) | 0.034 | 10/26 (38.5%) | 0.019 |
| No | 14/16 (87.5%) | 4/11 (36.4%) | 0.012 | 5/10 (50.0%) | 0.069 |
| Employment status | |||||
| Unemployed | 4/5 (80.0%) | 2/13 (15.4%) | 0.022 | 1/3 (33.3%) | 0.49 |
| Employed | 16/18 (88.9%) | 5/13 (38.5%) | 0.006 | 11/23 (47.8%) | 0.008 |
| On disability benefits | 3/6 (50.0%) | 2/4 (50.0%) | >0.99 | 2/7 (28.6%) | 0.59 |
| Student | 4/5 (80.0%) | 1/1 (100.0%) | >0.99 | 0/0 | N/A |
| Maternity leave/housewife | 2/2 (100.0%) | 1/1 (100.0%) | >0.99 | 0/1 (0.0%) | 0.33 |
| Retired | 0/0 | 3/4 (75.0%) | N/A | 1/2 (50.0%) | N/A |
| Marital status | |||||
| Single | 12/17 (70.6%) | 8/20 (40.0%) | 0.10 | 8/16 (50.0%) | 0.30 |
| Married | 16/18 (88.9%) | 5/13 (38.5%) | 0.006 | 7/16 (43.8%) | 0.009 |
| Divorced | 1/1 (100.0%) | 1/2 (50.0%) | >0.99 | 0/4 (0.0%) | 0.20 |
| Widowed | 0/0 | 0/1 (0.0%) | N/A | 0/0 | N/A |
| Highest education level | |||||
| Secondary school | 5/9 (55.6%) | 4/11 (36.4%) | 0.65 | 2/5 (40.0%) | >0.99 |
| College | 15/17 (88.2%) | 7/17 (41.2%) | 0.010 | 8/22 (36.4%) | 0.001 |
| Currently at university | 4/5 (80.0%) | 1/1 (100.0%) | >0.99 | 0/0 | N/A |
| University | 5/5 (100.0%) | 1/2 (50.0%) | 0.29 | 5/9 (55.6%) | 0.22 |
| No data | 0/0 | 1/5 (20.0%) | N/A | 0/0 | N/A |
*
p-Values show the result of Fisher's exact test, testing the null hypothesis that successful outcome rates are equal between cases and controls. A p-Value less than 0.05 indicates evidence of a statistically significant difference in the percentages of cases and control with successful outcomes.