Figure 6.

Artery tertiary lymphoid organ (ATLO) B-1 B cells show a predominant immunosuppressive IL-10⁺/PD-L1⁺/FasL⁺/TGFβ⁺ phenotype. Cell suspensions from individual aged ApoE^−/− mice. A, IL-10⁺, TGFβ⁺, PD-L1⁺, and FasL⁺ abdominal aorta B cells. B, ApoE^−/− (red) spleen (80- to 85-week old mice) and WT (blue); ApoE^−/− (n=3–4). B-1a, B-1b, and B-2 cell populations were gated and assayed for cytokine expression (or isotype control, black). Numbers designate frequencies of positive cells.