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. Author manuscript; available in PMC: 2016 Jun 6.
Published in final edited form as: Annu Rev Genomics Hum Genet. 2008;9:303–320. doi: 10.1146/annurev.genom.9.081307.164211

Figure 4.

Figure 4

Putative model by which cohesin can hinder and relieve transcriptional control (in this case transcriptional repression) of genes regulated by distal elements. (a) Cohesin loaded on the chromosome inhibits the propagation of a transcriptional control signal from a distal enhancer to increase transcription via the target promoter. (b) With release of cohesin from the chromosome, the transcription activation signal from the distal enhancer is free to propagate to the promoter and increase transcription of the target gene.