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UT Antagonist SB657510A (SB) inhibits UII and URP induced SMC calcification. SMCs were incubated in phosphate medium (PI) for 14 days with 100 nM UII or 100 nM URP, in the presence and absence of UT antagonist (SB) at concentration 10 μM. UII and URP stimulatory effect on SMC calcification was abolished in the presence of SB657510A. *P < 0.05 (n = 4 per experiment).
