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. 2016 Jun 7;4:55. doi: 10.3389/fcell.2016.00055

Table 1.

Studies reporting focal interactions between antimicrobial peptides and bacteria.

Authors Species Findings
Hasper et al., 2006 Bacillus subtilis and Bacillus megaterium Nisin disrupted septal and helical distribution of lipid II and aggregated with lipid II in the membrane.
Scherer et al., 2015 Bacillus subtilis Nisin inhomogeneously bound lipid II, forming aggregates that caused cell death.
Vega and Caparon, 2012 Streptococcus pyogenes Human neutrophil peptide 1 (HNP-1) and polymyxin B (PxB) disrupted anionic Exportal domain and delocalized the SecA translocase.
Kandaswamy et al., 2013 Enterococcus faecalis Human β-defensin 2 (hBD2) focally targeted cell surface and delocalized Sortase A (SrtA) and the SecA translocase.
Wenzel et al., 2014 Bacillus subtilis A 6-amino acid CAMP delocalized the peripheral membrane proteins MurG and cytochrome c.
Zweytick et al., 2014 E. coli Lactoferricin-derived N-acylated AMPs disrupted phosphatidylethanolamine (PE) and cardiolipin membrane domains and caused defective cell division.
Rangarajan et al., 2013 E. coli Cecroprin A permeabilized the outer and cytoplasmic membranes in discrete membrane regions.
Tran et al., 2013 Enterococcus faecalis Daptomycin targeted the division septum.
Pogliano et al., 2012 Bacillus subtilis Daptomycin delocalized cell division protein DivIVA.
Rangarajan et al., 2013 E. coli Cecroprin A caused localized permeabilization of the cell membrane
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