Table 1.
Studies reporting focal interactions between antimicrobial peptides and bacteria.
Authors | Species | Findings |
---|---|---|
Hasper et al., 2006 | Bacillus subtilis and Bacillus megaterium | Nisin disrupted septal and helical distribution of lipid II and aggregated with lipid II in the membrane. |
Scherer et al., 2015 | Bacillus subtilis | Nisin inhomogeneously bound lipid II, forming aggregates that caused cell death. |
Vega and Caparon, 2012 | Streptococcus pyogenes | Human neutrophil peptide 1 (HNP-1) and polymyxin B (PxB) disrupted anionic Exportal domain and delocalized the SecA translocase. |
Kandaswamy et al., 2013 | Enterococcus faecalis | Human β-defensin 2 (hBD2) focally targeted cell surface and delocalized Sortase A (SrtA) and the SecA translocase. |
Wenzel et al., 2014 | Bacillus subtilis | A 6-amino acid CAMP delocalized the peripheral membrane proteins MurG and cytochrome c. |
Zweytick et al., 2014 | E. coli | Lactoferricin-derived N-acylated AMPs disrupted phosphatidylethanolamine (PE) and cardiolipin membrane domains and caused defective cell division. |
Rangarajan et al., 2013 | E. coli | Cecroprin A permeabilized the outer and cytoplasmic membranes in discrete membrane regions. |
Tran et al., 2013 | Enterococcus faecalis | Daptomycin targeted the division septum. |
Pogliano et al., 2012 | Bacillus subtilis | Daptomycin delocalized cell division protein DivIVA. |
Rangarajan et al., 2013 | E. coli | Cecroprin A caused localized permeabilization of the cell membrane |