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. 2016 Jun 7;7:142. doi: 10.3389/fphar.2016.00142

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Copyright © 2016 Sasagawa, Nishimura, Sawada, Zhang, Okabe, Murakami, Ashikawa, Yuge, Kawaguchi, Kawase, Mitani, Maruyama and Tanaka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagram of DEGs in the five PAH transcriptome datasets. Transcriptome data from a rat PAH model caused by treatment with the VEGFR inhibitor SU5416 and hypoxia (GSE8078); a mouse PAH model caused by overexpression of Fra-2, a causative gene for systemic sclerosis (GSE51222); a mouse PAH model caused by schistosomiasis (GSE48936); and two cohorts of human PAH patients (GSE24988 and GSE53408) were downloaded from a public database (GEO). Genes that were differentially expressed in the PAH and control groups of each dataset were identified as described in the methods. The numbers of DEGss unique to each transcriptome dataset and shared between datasets are shown.