Table 2.
Results of multivariate logistic regression analysis of the rs10887800 polymorphism effect on CAD risk under three models of genetic inheritance
| Rs10887800 A > G Genotypes |
CAD+ n = 107 |
CAD− n = 202 |
CAD+ versus CAD− | |
|---|---|---|---|---|
| ORa (95 % CI) | p | |||
| Codominant model | ||||
| AA | 24 (22.4) | 53 (26.2) | Reference | – |
| AG | 51 (47.7) | 110 (54.5) | 1.41 (.71–2.80) | .322 |
| GG | 32 (29.9) | 39 (19.3) | 2.66 (1.19–5.94) | .017 |
| Dominant model | ||||
| AA | 24 (22.4) | 53 (26.2) | Reference | – |
| AG + GG | 83 (77.6) | 149 (73.8) | 1.72 (.90–3.29) | .100 |
| Recessive model | ||||
| AG + AA | 75 (70.1) | 163 (80.7) | Reference | – |
| GG | 32 (29.9) | 39 (19.3) | 2.10 (1.10–4.02) | .025 |
Genotype distribution is presented as numbers (%). HWE test for CAD+ χ 2 = .18, p = .669, for CAD− χ 2 = 1.80, p = .180
CAD coronary artery disease
aOdds ratios adjusted for age, sex, smoking status, BMI hyperlipidemia, arterial hypertension, diabetes mellitus and stroke in anamnesis