Table 3.
Results of multivariate logistic regression analysis of the rs2576178 polymorphism effect on CAD risk under three genetic models of inheritance
| Rs2576178 A > G Genotypes |
CAD+ n = 107 |
CAD− n = 202 |
CAD+ versus CAD− | |
|---|---|---|---|---|
| ORa (95 % CI) | p | |||
| Codominant model | ||||
| AA | 54 (50.5) | 114 (56.4) | Reference | – |
| AG | 43 (40.2) | 75 (37.1) | 1.38 (.77–2.46) | .269 |
| GG | 10 (9.3) | 13 (6.4) | 2.10 (.67–6.60) | .202 |
| Dominant model | ||||
| AA | 54 (50.5) | 114 (56.4) | Reference | – |
| AG + GG | 53 (49.5) | 88 (43.5) | 1.46 (.84–2.55) | .174 |
| Recessive model | ||||
| AG + AA | 97 (90.7) | 189 (93.5) | Reference | – |
| GG | 10 (9.3) | 13 (6.4) | 1.83 (.60–5.58) | .286 |
Genotype distribution is presented as numbers (%). HWE test for CAD+ χ 2 = .11, p = .735, for CAD− χ 2 = .02, p = .888
CAD coronary artery disease
aOdds ratios adjusted for age, sex, smoking status, BMI hyperlipidemia, arterial hypertension, diabetes mellitus and stroke in anamnesis