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Schematic anti-inflammatory signaling pathways activated by nAChR α7. Stimulation of nAChR α7 activates Jak2 leading to inhibition of NFκB and GSK3 but also to CREB activation. A separate signaling cascade involves activation of PKA and AKT enabling the nuclear translocation of Nrf2 (NFE2L2), which drives expression of HMOX1 (HO-1). This pathway elicits potent anti-inflammatory and neuroprotective effects
