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. 2016 May 26;7:11725. doi: 10.1038/ncomms11725

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(a) Schematic representation of cocaine-CPP procedure. (b) Cocaine-CPP expression indicated by mean CPP score (CS+ minus CS−)±s.e.m. At 5 mg kg⁻¹ cocaine dose, Baf53b^+/− heterozygous knockout mice (n=10) exhibited significantly attenuated CPP score compared with WT littermates (n=8). A two-way repeated-measures analysis of variance (ANOVA) revealed a significant main effect of genotype (F_1,16=6.99, P=0.02). No effect of conditioning was observed (F_1,16=2.05, P=0.17) but there was a significant interaction (F_1,16=4.93, P=0.04). Bonferroni post-hoc analysis showed no initial preference for either context on the pretest (t=0.46, P>0.05). However, there was a significant difference between the WT and Baf53b^+/− heterozygous mice on the posttest (t=3.45, P<0.01). (c) At 10 mg kg⁻¹ cocaine dose, Baf53b^+/− heterozygous knockout mice (n=9) exhibit similar CPP score to WT littermates (n=8). Using a two-way repeated-measures ANOVA, we found a significant main effect of conditioning (F_1,17=112.81, P<0.0001) but not genotype (F_1,17=0.24, P=0.63) and no interaction (F_1,17=0.14, P=0.71). Bonferroni post-hoc analysis showed no difference between the WT and the Baf53b^+/− heterozygous mice on the pretest (t=0.21, P>0.05) or posttest (t=0.61, P>0.05). (d) At 5 mg kg⁻¹ cocaine dose, Baf53bΔHD mice (n=9) exhibited significantly attenuated CPP score compared with WT littermates (n=10). Using a two-way repeated-measures ANOVA, we found significant main effects on conditioning (F_1,17=29.19, P<0.0001) and genotype (F_1,17=5.62, P=0.03), but no interaction (F_1,17=2.56, P=0.13). Bonferroni post-hoc analysis showed no differences between the preference of WT and Baf53bΔHD mice for either context on the pretest (t=0.83, P>0.05) but a significant difference on the posttest (t=2.85, P<0.05). (e) At a 10-mg kg⁻¹ cocaine dose, Baf53bΔHD mice (n=10) exhibited significantly attenuated CPP score compared with WT littermates (n=7). A two-way repeated-measures ANOVA revealed significant main effects of conditioning (F_1,15=47.37, P<0.0001), genotype (F_1,15=7.91, P=0.01) and an interaction (F_1,15=5.71, P=0.03). Bonferroni post-hoc analysis showed no differences between the preference of WT and BAF53bΔHD.