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. 2016 Jun 6;23(6):451–459. doi: 10.1128/CVI.00720-15

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Copyright © 2016 Cimica et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — Cytokine responses in VLP-vaccinated mouse lungs after RSV infection. (A) The cytokines for the Th1-mediated response are IFN-γ, IL-12p40, and TNF-α. (B) The Th2-mediated response cytokine measurement includes IL-4, IL-5, and IL-13. (C) The IL-17 and IL-1β analysis indicates the Th17-mediated response. (D) The IL-10 cytokine analysis demonstrates immunoregulatory process development. The results were generated using a group of 4 mice for each condition at 4 days postinfection. An asterisk indicates a statistically significant difference between the experimental condition and the placebo control; differences between the FI-RSV and VLP vaccines were statistically significant (P < 0.05) in all groups, with the exception of the prefusion group in the IFN-γ assay. ND, not detectable.