Schematic models of HA complexes to illustrate the positional variations of constituent HA molecules. (A to D) Schematics of five, six, seven, and eight HA trimers, respectively, in planar starfish-like arrangements. (E) Schematic of seven HA trimers in an asymmetric starfish-like arrangement with one molecule in an upward-facing position. (F) Schematic of seven HA trimers in an asymmetric starfish-like arrangement with one molecule in an upward-facing position and various distances between lateral molecules. In panels E and F, one HA molecule is perpendicular in order to indicate a top axial view as opposed to lateral views. In all the schematic models, HA1 is shown in red, HA2 in blue, and transmembrane regions in gray.