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. 2016 May 31;7:11664. doi: 10.1038/ncomms11664

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(a) Representative images from the liver tissues by immunohistochemistry staining are shown for INTS10, p-p65 and p-IRF3, respectively. The scale bar represents 50 μm. (b,c) The correlation of protein levels between INTS10 and p-IRF3 (b), or between INTS10 and p-p65 (c). Protein levels of INTS10, p-p65 and p-IRF3 were measured in the non-tumour liver tissues of patients with HBV-related HCC by immunohistochemistry staining (n=40). The size of the circle is proportional to the number of samples. A Spearman's test was used, and the correlation coefficiency (ρ) and the two-tailed P values are shown. (d) The concentration of the plasma INTS10 in persistently HBV infected subjects (PIs) and spontaneously recovered subjects (SRs). The plasma INTS10 levels were measured by enzyme-linked immunosorbent assays (ELISA) in 216 PIs and 80 SRs. Horizontal bars indicate the mean value of each subset. The significance was calculated using two-tailed unpaired t test. (e) Correlation between the plasma INTS10 and HBV DNA load in PIs with positive HBeAg (left) and PIs with negative HBeAg (right). The plasma INTS10 and HBV DNA load were log10 transformed. The correlation coefficiency (r) and the two-tailed P values were then evaluated by Pearson's test. P values were considered to be significant when below 0.05.