Table 2. Association results for the rs7000921 at 8p21.3 in five case–control populations.
| Studies | Cases* | Controls* | ORs (95% CI) | P values |
|---|---|---|---|---|
| GWAS | 60/464/727 | 83/433/540 | 0.66 (0.56–0.79) | 2.4 × 10−6 |
| Replication 1 | 72/481/724 | 105/543/708 | 0.84 (0.74–0.95) | 6.7 × 10−3 |
| Replication 2 | 62/459/752 | 83/423/555 | 0.77 (0.68–0.88) | 1.4 × 10−4 |
| Replication 3 | 48/314/376 | 39/255/218 | 0.78 (0.65–0.94) | 9.1 × 10−3 |
| Replication 4 | 25/185/303 | 25/140/196 | 0.80 (0.64–1.02) | 6.8 × 10−2 |
| Overall | 267/1,903/2,882 | 335/1,794/2,217 | 0.78 (0.73–0.84) | 3.2 × 10−12 |
CI, confidence interval; cases, persistently HBV infected subjects (PIs); controls, spontaneously recovered subjects (SRs).
The GWAS population contains three independent case–control sub-populations of Southern Chinese ancestry, namely the Guangxi-GWAS population, the Jiangsu-GWAS population and the Guangdong-GWAS population (see Supplementary Note). Replication 1, 2, 3 and 4 samples are from Jiangsu, Jiangxi, Guangdong and Beijing, respectively. In GWAS population, ORs and 95% CIs were calculated under additive model by logistic regression while adjusting for age, sex and two admixture principal components. In the replication stage, ORs and 95% CIs were calculated under additive model by logistic regression while adjusting for age and sex. In overall samples, the meta-analysis gave a joint P value and a joint OR, with the P value for heterogeneity 0.29.
*Counts of minor allele homozygote (CC)/heterozygote (CT)/major allele homozygote (TT) genotypes in the cases and controls, respectively. The number of genotyped samples varies due to genotyping failure.