Table 2.
The frequency of genotypes and alleles of the CYBA gene ∗49A>G polymorphism in the groups of patients (CAD) and blood donors (BD).
| Genotype, allele | CAD (N = 242) % (n) | BD (N = 239) % (n) | Versus | OR (95% CI), P univariate analysis | Power (%) 95% CL |
|---|---|---|---|---|---|
| AA | 15.2 (37) | 23.4 (56) | GG+AG | 0.59 (0.36–0.96), 0.0201 | 61 |
| AG | 45.1 (109) | 45.2 (108) | — | — | — |
| GG | 39.7 (96) | 31.4 (75) | AA+AG | 1.44 (0.97–2.13), 0.0572 | 47 |
| AA+AG | 60.3 (146) | 68.6 (164) | GG | 0.70 (0.47–1.03), 0.0573 | 47 |
| GG+AG | 84.8 (205) | 76.6 (183) | AA | 1.70 (1.04–2.76), 0.0204 | 61 |
| ∗49A | 37.8 (183) | 46.0 (220) | ∗49G | 0.71 (0.55–0.93), 0.009 | 72 |
| ∗49G | 62.2 (301) | 54.0 (258) | ∗49A | 1.40 (1.08–1.83), 0.009 | 72 |
The results of multivariate analysis after adjustment for sex, age, TC, LDL-chol, HDL-chol, TG, BMI, diabetes mellitus, cigarette smoking status, hypertension, and familial history of CAD.
1OR = 0.45, 95% CI; 0.25–0.83, P = 0.011.
2OR = 2.05, 95% CI; 1.24–3.38, P = 0.005.
3OR = 0.48, 95% CI; 0.30–0.81, P = 0.005.
4OR = 2.19, 95% CI; 1.20–3.99, P = 0.011.
CAD: coronary artery disease patients, BD: blood donors, OR: odds ratio, CI: confidence interval, and CL: confidence level.