TABLE 1 .

The genes that were most up- or downregulated at the intersection of the time points of the acute phase of LGTV infection^a

Gene category	12 hpi versus:
	24 hpi		48 hpi		72 hpi		96 hpi
	Gene	Fold change	Gene	Fold change	Gene	Fold change	Gene	Fold change
Upregulated	LGI1	8.99	NUPR1	28.22	NUPR1	75.32	NUPR1	131.57
	NUPR1	7.93	OSTN	10.06	KRTAP19-1	16.31	GAS5	64.87
	RPS17	6.69	LGI1	8.73	OSTN	14.41	IFIT1	60.32
	RPS29	4.52	CTH	7.41	ASS1	13.82	KRTAP19-1	35.33
	RPS3A	4.51	RPS17	7.19	CTH	12.2	RPL9	25.02
	RPL9	4.48	CHAC1	7.04	GAS5	12.19	CCNB1PIP1	24.6
	RSL24D1	4.39	GAS5	7	RPL9	10.18	RMRP	21.9
	RPL22L1	4.37	IFIT1	6.83	LGI1	9.29	LGI1	20.69
	RPL34	4.26	ASS1	6.65	RSL24D1	9.26	RPL26	20.16
	RPL36A	4.23	CCNB1PIP	16.08	CCNB1PIP	18.74	RPL39	19.6
Downregulated	CXCL1	24.97	CXCL1	9.14	CYP1B1	16.64	LGR5	14.8
	OAS3	14.77	OAS3	7.95	SHISA2	13.81	C22orf46	14.46
	NES	6.07	CYP1B1	6.62	NEAT1	11.11	DNAJC22	12.97
	FZD10	4.81	NEAT1	6.22	DOK3	10.79	CYP1B1	12.94
	MAGEA3	4.64	OSMR	5.5	FZD10	10.63	CRIPAK	12.79
	CYP1B1	4.59	NES	4.83	CRIPAK	8.54	DOK3	12.73
	NEAT1	4.21	SPEN	4.74	MAP1A	8.27	SHISA2	12.48
	SHISA2	3.9	FOXD4	4.65	C22orf46	7.22	TRIM66	11.59
	CRIPAK	3.81	LGR5	4.64	PCDH7	7.17	TRIM56	11.48
	HLA-DOA	3.77	SHISA2	4.61	TRIM66	6.65	MAP1A	11.16

^aA total of 519 genes were significantly differentially expressed at the intersection of all acute-phase time points, and these were analyzed with IPA to reveal those that were the most (fold change) up- or downregulated in expression at 24, 48, 72, and 96 hpi.