TABLE 1 .
Block | Clades | Starta | Stopa | Length (kb) |
SNPs | Genes | M-like | % ID |
---|---|---|---|---|---|---|---|---|
RB1b | C1-C2 | 92,389 | 164,162 | 71,774 | 411 | 72 | M2 | 88.74b |
RB2 | C1-C2 | 295,481 | 297,574 | 2,094 | 9 | 2 | M2 | 100.00 |
RB3c | C1-C2 | 773,487 | 780,634 | 7,148 | 55 | 8 | M2 | 99.55 |
RB4c | C1-C2 | 794,417 | 800,659 | 6,243 | 28 | 8 | M2 | 99.55 |
RB5 | C1-C2 | 921,261 | 960,297 | 39,037 | 100 | 41 | M2 | 99.68 |
RB6 | C1-C2 | 1,022,619 | 1,030,407 | 7,789 | 20 | 6 | M2 | 99.97 |
RB7 | C1-C2 | 1,543,651 | 1,561,165 | 17,515 | 103 | 13 | M2 | 97.17 |
RB8 | C1-C2 | 1,577,916 | 1,597,447 | 19,532 | 138 | 21 | M28 | 99.58 |
RB9 | C2-C3 | 86,603 | 88,366 | 1,764 | 12 | 2 | M5/M23 | 99.38 |
RB10 | C2-C3 | 145,163 | 155,569 | 10,407 | 59 | 11 | M1/M12 | 98.52 |
RB11 | C2-C3 | 244,407 | 244,758 | 352 | 5 | 1 | M5 | 100.00 |
RB12 | C2-C3 | 1,472,262 | 1,473,025 | 764 | 9 | 1 | M12 | 100.00 |
RB13 | C2-C3 | 1,558,898 | 1,559,698 | 801 | 7 | 2 | M49 | 99.75 |
RB14 | C2-C3 | 1,693,613 | 1,694,805 | 1,193 | 6 | 2 | M5/M6 | 100.00 |
RB15 | C3-SC3D | 341,762 | 359,579 | 17,818 | 106 | 21 | M1 | 99.67 |
The start and stop positions provided are relative to the MGAS23530 genome.
The first 18.6 kb and last 39.6 kb are M2-like (>99% identity [ID]); however, the central 13.5 kb FCT pilus-encoding region is unlike that of any other sequenced GAS emm-type.
RB3 and RB4 likely represent a single HGT event that encompasses the intervening streptin lantibiotic synthesis genes, thus resulting in a larger single recombination of 26,697 bp.