TABLE 1 .

HGT recombination blocks separating GAS emm89/M89 clades

Block	Clades	Starta	Stopa	Length (kb)	SNPs	Genes	M-like	% ID
RB1b	C1-C2	92,389	164,162	71,774	411	72	M2	88.74b
RB2	C1-C2	295,481	297,574	2,094	9	2	M2	100.00
RB3c	C1-C2	773,487	780,634	7,148	55	8	M2	99.55
RB4c	C1-C2	794,417	800,659	6,243	28	8	M2	99.55
RB5	C1-C2	921,261	960,297	39,037	100	41	M2	99.68
RB6	C1-C2	1,022,619	1,030,407	7,789	20	6	M2	99.97
RB7	C1-C2	1,543,651	1,561,165	17,515	103	13	M2	97.17
RB8	C1-C2	1,577,916	1,597,447	19,532	138	21	M28	99.58
RB9	C2-C3	86,603	88,366	1,764	12	2	M5/M23	99.38
RB10	C2-C3	145,163	155,569	10,407	59	11	M1/M12	98.52
RB11	C2-C3	244,407	244,758	352	5	1	M5	100.00
RB12	C2-C3	1,472,262	1,473,025	764	9	1	M12	100.00
RB13	C2-C3	1,558,898	1,559,698	801	7	2	M49	99.75
RB14	C2-C3	1,693,613	1,694,805	1,193	6	2	M5/M6	100.00
RB15	C3-SC3D	341,762	359,579	17,818	106	21	M1	99.67

^aThe start and stop positions provided are relative to the MGAS23530 genome.

^bThe first 18.6 kb and last 39.6 kb are M2-like (>99% identity [ID]); however, the central 13.5 kb FCT pilus-encoding region is unlike that of any other sequenced GAS emm-type.

^cRB3 and RB4 likely represent a single HGT event that encompasses the intervening streptin lantibiotic synthesis genes, thus resulting in a larger single recombination of 26,697 bp.