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. 2016 Jun 7;3(3):ENEURO.0094-16.2016. doi: 10.1523/ENEURO.0094-16.2016

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Copyright © 2016 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — I_NaP facilitates rebound burst generation and is regulated by the estrous cycle. A, ramp protocol (top) and representative raw currents (bottom) under control conditions (black) and after application of TTX (red). Dashed line indicates the linear fit to correct for leak current. B, Representative TTX-sensitive I_NaP obtained by subtracting the TTX trace from the control trace in A after linear fit of each. C, Representative I_NaP in cells that exhibit rebound bursts (red) or no rebound spikes (blue) on diestrus and those that exhibited rebound bursts on proestrus (black). D, E, Mean ± SEM I_NaP current density on di vs pro (D) and with cells parsed by cycle stage and rebound firing (E). *p < 0.05 calculated by two-way RM ANOVA and Holm–Sidak test.