Figure 1. Body weight, kidney weights and systolic blood pressure.

(a) Time course of body weight changes of experimental mice. Body weight in db/db mice significantly increased compared with db/+ mice. (b) Kidney weight of experimental mice at 16 weeks of age. db/db Ca_v2.2^−/− mice showed less renal hypertrophy than that of db/db Ca_v2.2^+/+ mice. (c,d) Time course of systolic blood pressure changes of db/+ mouse groups (c) and db/db mouse groups (d). (e,f) Urinary catecholamine of experimental mice at 16 weeks of age. db/db Ca_v2.2^−/− mice showed lower levels of urinary noradrenaline (e) and adrenaline (f) than db/db Ca_v2.2^+/+ mice. db/+ Ca_v2.2^+/+ mice (n = 7, white circles), db/+ Ca_v2.2^+/− mice (n = 6, white triangles), db/+ Ca_v2.2^−/− mice (n = 7, white squares), db/db Ca_v2.2^+/+ mice (n = 8, black circles), db/db Ca_v2.2^+/− mice (n = 8, black triangles), and db/db Ca_v2.2^−/− mice (n = 8, black squares). *p < 0.05, **p < 0.01 vs. Ca_v2.2^+/+ mice of the same db genotype.