Fig. 2.
UA inhibits TPA-induced transformation in JB6P+ cells. Cells (8 × 103/ml) in 1 ml of BME containing 0.33% agar were maintained in the presence of DMSO (control, a), TPA alone (b), UA 1 μM plus TPA (c) and UA 2.5 μM plus TPA. After 2 weeks, the cell colonies were counted. The data are presented as the mean ± S.D. ***p < 0.0001 compared with TPA alone.