Table 8.
Structure and Activity of KF
| amino acids | SAR | domain | SAR | |
|---|---|---|---|---|
| 1 | l-Val | l configuration is important | A | ring is essential |
| 2 | (Z)-Dhb | double bond is crucial |
l/d configuration of the α-carbon of the backbone that maintains the conformation of the ring is crucial |
|
| 3 | l-Phe | A hydrophobic residue can increase the activity | ||
| 4 | d-Val | d configuration is important | ||
| 5 | d-allo-Ile | d configuration is important | ||
| 6 | d-allo-Thr | configurations of two chiral centers are very important |
||
| 7 | d-allo-Ile | d configuration is important | B | configuration of the α-carbons of the amino acids is crucial; domain adopts or induces some sort of folding and/or interactions with other molecules |
| 8 | l-Orn | aliphatic groups coupled to the amino group of Orn can increase the activity |
||
| 9 | d-Pro | d configuration and the ring are important | ||
| 10 | d-Val | d configuration is important | ||
| 11 | l-Val | l configuration is important | ||
| 12 | l-Thr |
l configuration is important, and aliphatic substitutions can increase the activity |
||
| 13 | d-Val | d configuration is important | ||
| 14 | 5-MeHex | long aliphatic group is essential | C | domain does not interact selectively with any other molecule, and its main function is as an aliphatic buoy |