Table 3.
Characteristics of patients (pt) diagnosed with Her2+ metastatic breast cancer (MBC) who survived at least 5 years (yr) following diagnosis of central nervous system (CNS) metastasis (N=9).
| Pt | Age at initial diagnosis | Stage | HR status | Time initial dx to MBC (yr) | Time MBC to CNS met (yr) | Biopsy-proven met | Radiation therapy | Surgical resection | Anti-Her2 therapy after CNS met | Overall survival since CNS met diagnosis (yrs)* |
|---|---|---|---|---|---|---|---|---|---|---|
| 76 | 46 | II | + | 2.0 | 5.4 | Yes | WBRT | No | Yes | 5.0 |
| 74 | 36 | II | + | 3.7 | At diagnosis | Yes | SRS | Yes | Yes | 5.4 |
| 189 | 37 | II | − | 2.2 | 1.3 | Yes | SRS, WBRT | No | Yes | 5.6 |
| 160 | 40 | I | + | 9.2 | 3.8 | Yes | WBRT | Yes | Yes | 6.0 |
| 108 | 52 | IV | + | At diagnosis | 2.1 | Yes | WBRT | Yes | Yes | >6.0 |
| 63 | 40 | IV | − | At diagnosis | 1.0 | Yes | WBRT | Yes | Yes | >7.9 |
| 61 | 36 | II | + | 3.6 | 1.7 | Yes | WBRT | Yes | Yes | >8.3 |
| 85 | 38 | I | + | 2.5 | At diagnosis | Yes | WBRT | Yes | Yes | >8.4 |
| 176 | 42 | II | − | 1.9 | 0.8 | Yes | WBRT, SRS | Yes | Yes | >13.3 |
Abbreviations: HR: hormone receptor; met: metastasis; SRS: stereotactic radiosurgery; WBRT: whole brain radiation therapy.
*
Survival for patients still alive at time of data cutoff is censored.