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. 2016 Jun 7;6:27015. doi: 10.1038/srep27015

Figure 1. Intra-hippocampal injection of HDAC inhibitor after learning promotes spatial long term memory.

Figure 1

(A) Schematic of the experimental procedure. (B) Mean latency (in sec) to find the platform during the four training sessions of the spatial Morris water maze task. Immediately after training, mice received an intra-hippocampal injection of saline (n = 19) or NaB (n = 20). (C) Difference of latencies (Δ latency) between the last session of acquisition and the first target crossing of the 24 h-probe test. (D–G) Number of annuli crossings (+SEM) and time spent in each quadrant (+SEM) during the 60-sec probe test given 1 h (D,F) or 24 h (E,G) after injection. The dotted line represents the chance level. *P < 0.05; **P < 0.01 and ***P < 0.001 target vs. others. °P < 0.05; °°P < 0.01 and °°°P < 0.001 quadrant vs. chance level (15 sec). #P < 0.05 target Saline vs. target NaB.