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. 2016 Jun 7;6:27112. doi: 10.1038/srep27112

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CtsD fluorometric activity in kidney lysates assessed by the cleavage of a specific fluorescently labelled substrate (A) in sham and IRI vehicle or Pepstatin A treated animals. Percentage of tubular cell injury as assessed by tubular dilatation and granular cast formation in CMJ (B) of IRI vehicle or Pepstatin A treated kidneys. Representative PAS pictures, damaged cells pointed with a * (C) of sham or IRI vehicle or Pepstatin A treated kidneys. Ischemia was performed for 25 minutes and kidneys were reperfused for 24 hours. Animals were treated with vehicle or Pepstatin A 10 mg/Kg 1 hour before surgery and 4 hours post-surgery. N = 7, 1 way ANOVA or t-test,*P ≤ 0.05 or **P ≤ 0.01.