Table 1.
Gene Ontology categories enriched by differentially expressed genes among TB, LTBI, and healthy control (HC)
| TB vs. HC | LTBI vs. HC | LTBI vs. TB |
|---|---|---|
| 1. Immune response | Regulation of metabolic process | Response to cold |
| 2. Leukocyte differentiation | Regulation of cellular Metabolic process | Immune Response-regulating signaling pathway |
| 3. Immune system process | Regulation of biosynthetic process | Cellular process |
| 4. B cell activation | Apoptotic process | Immune response- activating signal transduction |
| 5. Lymphocyte differentiation | Death | Heterotypic cell-cell adhesion |
| 6. Regulation of immune response | Regulation of gene expression | NK T cell differentiation |
| 7. Positive regulation of response to stimulus | MAP kinase phosphatase activity | Regulation of mRNA catabolic process |
| 8. Lymphocyte activation | Translation factor activity, | Translation regulator activity |
| 9. Leukocyte activation | Translation initiation factor activity | NF-kappaB binding |
| 10. Chemokine receptor activity | Protein tyrosine/threonine phosphatase activity | Translation repressor activity |
WebGestalt setting: multiple test adjustment = Benjamini-Hochberg, significance level = top 10 (Benjamini-Hochberg adjusted p < 0.05); minimum number of genes for a category = 2