Table 3.
Genes differentially expressed in ISIAH versus WAG renal cortex and annotated in databases as associated with hypertension and blood pressure regulation
| Gene symbol | Acc. # | Gene name | log2 fold change ISIAH/WAG |
|---|---|---|---|
| Rat genome database | |||
| Ace a bc | NM_012544.1 | Angiotensin I converting enzyme | −1.18 |
| Acsm3 c | XM_006230106.1 | Acyl-CoA synthetase medium-chain family member 3, transcript variant X2 | 2.51 |
| Adra1b b | NM_016991.2 | Adrenoceptor alpha 1B | −1.24 |
| Adra2a | NM_012739.3 | Adrenoceptor alpha 2A | −1.01 |
| Alas1 | NM_024484.2 | Aminolevulinate, delta-, synthase 1 | 0.47 |
| Angpt1 | XM_006241609.1 | Angiopoietin 1, transcript variant X1 | 0.69 |
| Apob a bc | NM_019287.2 | Apolipoprotein B | −2.52 |
| Arg2 a c | NM_019168.1 | Arginase 2 | −0.58 |
| Cdo1 | XM_006254698.1 | Cysteine dioxygenase type 1, transcript variant X1 | −0.78 |
| Clu a c | XM_006252094.1 | Clusterin, transcript variant X1 | −1.75 |
| Comt | NM_012531.2 | Catechol-O-methyltransferase | −0.82 |
| Cst3 a bc | NM_012837.1 | Cystatin C | −0.50 |
| Cyp1a1 c | NM_012540.2 | Cytochrome P450, family 1, subfamily a, polypeptide 1 | −1.04 |
| Cyp2j4 a | NM_023025.2 | Cytochrome P450, family 2, subfamily j, polypeptide 4 | −0.81 |
| Cyp4a8 | NM_031605.2 | Cytochrome P450, family 4, subfamily a, polypeptide 8 | −0.55 |
| Ephx1 c | NM_012844.3 | Epoxide hydrolase 1, microsomal (xenobiotic), transcript variant 2 | 0.59 |
| Ephx2 a b | XM_006252147.1 | Epoxide hydrolase 2, cytoplasmic, transcript variant X1 | 4.48 |
| Gja1 c | XM_006256503.1 | Gap junction protein, alpha 1, transcript variant X2 | 0.54 |
| Glp1r | XR_362044.1 | Glucagon-like peptide 1 receptor, transcript variant X1 | 3.79 |
| Hsd11b2 c | NM_017081.2 | Hydroxysteroid 11-beta dehydrogenase 2 | 0.60 |
| Itgav b | XM_006234437.1 | Integrin, alpha V | −0.62 |
| Klk1c12 ab | NM_001005382.1 | Kallikrein 1-related peptidase C12 | −1.86 |
| Klkb1 ac | XM_006253121.1 | Kallikrein B, plasma 1, transcript variant X1 | 2.22 |
| Mif bc | NM_031051.1 | Macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 0.50 |
| Mmp9 ac | XM_006235619.1 | Matrix metallopeptidase 9, transcript variant X1 | −2.49 |
| Mthfr ac | XM_006239414.1 | Methylenetetrahydrofolate reductase (NAD(P)H), transcript variant X2 | 0.49 |
| Ppara bc | XM_006242154.1 | Peroxisome proliferator activated receptor alpha, transcript variant X4 | −0.56 |
| Ptgds a b | NM_013015.2 | Prostaglandin D2 synthase (brain) | −0.67 |
| Ptk2b bc | XM_006252145.1 | Protein tyrosine kinase 2 beta, transcript variant X3 | −0.51 |
| Ren a | NM_012642.4 | Renin | −0.49 |
| RT1-Bb c | NM_001004084.2 | RT1 class II, locus Bb | −0.78 |
| Slc26a4 | XM_006239978.1 | Solute carrier family 26 (anion exchanger), member 4, transcript variant X3 | 0.46 |
| Slc2a4 b | NM_012751.1 | Solute carrier family 2 (facilitated glucose transporter), member 4 | −0.77 |
| Slc9a3r2 | XM_006245893.1 | Solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2, transcript variant X2 | −0.48 |
| Sncg | NM_031688.1 | Synuclein, gamma (breast cancer-specific protein 1) | −1.25 |
| Sts | XM_006256960.1 | Steroid sulfatase (microsomal), isozyme S, transcript variant X1 | −0.70 |
| Tf a bc | NM_001013110.1 | Transferrin | −1.50 |
| Vwf bc | NM_053889.1 | Von Willebrand factor | 0.77 |
| Xdh a c | NM_017154.1 | Santhine dehydrogenase | −0.77 |
| David (regulation of blood pressure) | |||
| Guca2b | NM_022284.2 | Guanylate cyclase activator 2B | 2.04 |
| P2rx4 | NM_031594.1 | Purinergic receptor P2X, ligand-gated ion channel 4 | −1.65 |
| Pcsk5 | XM_006231145.1 | Proprotein convertase subtilisin/kexin type 5, transcript variant X2 | 0.53 |
Genes associated with: a-diabetic nephropathy; b-insulin resistance; c -immune system diseases