Table 4.
Genes differentially expressed in ISIAH versus WAG renal cortex and annotated in rat genome database as associated with kidney diseases
| Gene symbol | Acc. # | Gene name | log2 fold change ISIAH/WAG |
|---|---|---|---|
| Abcb1a b | NM_133401.1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1A | −0.82 |
| Abcc2 b | NM_012833.1 | ATP-binding cassette, subfamily C (CFTR/MRP), member 2 | −0.47 |
| Ace abcd | NM_012544.1 | Angiotensin I converting enzyme | −1.18 |
| Acsm3 c | XM_006230106.1 | Acyl-CoA synthetase medium-chain family member 3, transcript variant X2 | 2.51 |
| Aif1 c | NM_017196.3 | Allograft inflammatory factor 1 | 0.59 |
| Angpt1 | XM_006241609.1 | Angiopoietin 1, transcript variant X1 | 0.69 |
| Apob d | NM_019287.2 | Apolipoprotein B | −2.52 |
| Apoc2 b | XM_006228403.1 | Apolipoprotein C-II, transcript variant X1 | −1.20 |
| Apoh d | NM_001009626.1 | Apolipoprotein H (beta-2-glycoprotein I) | −2.73 |
| Arg2 bd | NM_019168.1 | Arginase 2 | −0.58 |
| Atp6v1b1 | XM_006236748.1 | ATPase, H transporting, lysosomal V1 subunit B1, transcript variant X1 | 0.57 |
| Bak1 | NM_053812.1 | BCL2-antagonist/killer 1 | 0.54 |
| Bsnd | NM_138979.2 | Bartter syndrome, infantile, with sensorineural deafness (Barttin) | 0.45 |
| C1qa c | NM_001008515.1 | Complement component 1, q subcomponent, A chain | 0.59 |
| Cfb abc | NM_212466.3 | Complement factor B | −1.09 |
| Clu abcd | XM_006252094.1 | Clusterin, transcript variant X1 | −1.75 |
| Cndp1 cd | NM_001007687.1 | Carnosine dipeptidase 1 (metallopeptidase M20 family) | −1.01 |
| Col3a1 ab | NM_032085.1 | Collagen, type III, alpha 1 | −0.60 |
| Comt | NM_012531.2 | Catechol-O-methyltransferase | −0.82 |
| Cst3 d | NM_012837.1 | Cystatin C | −0.50 |
| Cyp1a1 b | NM_012540.2 | Cytochrome P450, family 1, subfamily a, polypeptide 1 | −1.04 |
| Cyp2j4 ad | NM_023025.2 | Cytochrome P450, family 2, subfamily j, polypeptide 4 | −0.81 |
| Cyp4a8 | NM_031605.2 | Cytochrome P450, family 4, subfamily a, polypeptide 8 | −0.55 |
| Ephx2 bd | XM_006252147.1 | Epoxide hydrolase 2, cytoplasmic, transcript variant X1 | 4.48 |
| Fga b | NM_001008724.1 | Fibrinogen alpha chain, transcript variant 1 | 1.00 |
| Fhit | NM_021774.1 | Fragile histidine triad | 0.80 |
| Fmod d | XM_006249885.1 | Fibromodulin, transcript variant X1 | −0.94 |
| Gatm b | NM_031031.2 | Glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.74 |
| Gfpt2 d | NM_001002819.2 | Glutamine-fructose-6-phosphate transaminase 2 | 1.75 |
| Gja1 | XM_006256503.1 | Gap junction protein, alpha 1, transcript variant X2 | 0.54 |
| Gtpbp4 b | XM_006254146.1 | GTP binding protein 4 | 1.77 |
| Hao1 | XM_006235096.1 | Hydroxyacid oxidase (glycolate oxidase) 1, transcript variant X1 | −1.68 |
| Igfbp1 d | NM_013144.1 | Insulin-like growth factor binding protein 1 | 1.09 |
| Itgal | XM_006230269.1 | Integrin, alpha L, transcript variant X1 | 0.71 |
| Kit | XM_006250909.1 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, transcript variant X1 | 0.62 |
| Klk1c12 d | NM_001005382.1 | Kallikrein 1-related peptidase C12 | −1.86 |
| Klkb1 cd | XM_006253121.1 | Kallikrein B, plasma 1, transcript variant X1 | 2.22 |
| Lgals1 | NM_019904.1 | Lectin, galactoside-binding, soluble, 1 | 0.91 |
| Mif c | NM_031051.1 | Macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 0.50 |
| Mme c | NM_012608.2 | Membrane metallo-endopeptidase | 0.55 |
| Mmp9 acd | XM_006235619.1 | Matrix metallopeptidase 9, transcript variant X1 | −2.49 |
| Mthfr bcde | XM_006239414.1 | Methylenetetrahydrofolate reductase (NAD(P)H), transcript variant X2 | 0.49 |
| Muc20 bc | XM_006248449.1 | Mucin 20, cell surface associated, transcript variant X1 | 0.63 |
| Pla2g7 abc | XM_006244606.1 | Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma), transcript variant X1 | 0.71 |
| Ppara c | XM_006242154.1 | Peroxisome proliferator activated receptor alpha, transcript variant X4 | −0.56 |
| Ptgds de | NM_013015.2 | Prostaglandin D2 synthase (brain) | −0.67 |
| Ptk2b c | XM_006252145.1 | Protein tyrosine kinase 2 beta, transcript variant X3 | −0.51 |
| Ren bd | NM_012642.4 | Renin | −0.49 |
| Rhcg b | NM_183053.1 | Rh family, C glycoprotein | 0.66 |
| RT1-Bb a | NM_001004084.2 | RT1 class II, locus Bb | −0.78 |
| Serpinf1 d | NM_177927.2 | Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | −1.34 |
| Slc17a2 | NM_001107353.1 | Solute carrier family 17, member 2 | 0.52 |
| Slc19a3 b | NM_001108228.1 | Solute carrier family 19 (thiamine transporter), member 3 | 0.66 |
| Slc4a1 | XM_006247255.1 | Solute carrier family 4 (anion exchanger), member 1, transcript variant X1 | 0.86 |
| Tf cd | NM_001013110.1 | Transferrin | −1.50 |
| Tgfbi d | NM_053802.1 | Transforming growth factor, beta induced | −0.93 |
| Ttc21b | NM_001191737.1 | Tetratricopeptide repeat domain 21B | −0.48 |
| Vwf abc | NM_053889.1 | Von Willebrand factor | 0.77 |
| Wfs1 | NM_031823.1 | Wolfram syndrome 1 (wolframin) | 0.50 |
| Xdh abd | NM_017154.1 | Xanthine dehydrogenase | −0.77 |
Genes associated with: a-renal fibrosis; b -renal insufficiency; c-glomerulonephritis, d-diabetic nephropathies; e-nephrosclerosis