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. 2015 Dec 17;15(Suppl 1):156. doi: 10.1186/s12886-015-0132-x

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© Jester et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Meibography of the rabbit eyelids from normal (a), and 2 % epinephrine treated eyes for 1–2 months (b), 3–4 months (c) and 6 months (d). Normal glands (a. curved arrow) appear as grape-like clusters of individual acini (small arrow) with indistinct gland orifices (a, arrowheads). After 1–2 months of treatment, the orifices of the glands become detectible as dark spots at the leading edge of the glands (b, arrowheads). Progression of hyperkeratinization into the gland is detected by 3–4 months after treatment as large, dark cystic structure that obscure the normal acini (c, arrows). After six months of treatment the meibomian glands are replaced by large, dense keratic cysts (d). Magnification A-C: 24x and D: 10x