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Both the amount and rate of growth during appendage regeneration are variable and are proportional to the amount of tissue that is removed by amputation. The lower curve shows growth over time from a distal amputation (less tissue removed) and the upper curve from a proximal amputation (more tissue removed). Growth rate is proportional to the disparity created such that regeneration is complete at the same time regardless of the amount to be replaced. From Iten and Bryant (1973).
