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. 2016 Jun 7;6:27478. doi: 10.1038/srep27478

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Copyright © 2016, Macmillan Publishers Limited

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Circulating PMAs, platelet surface P-selectin expression (P-SEL), and integrin αIIbβ3 activation were measured by whole blood flow cytometry immediately prior to surgery and again 24 hours post-operatively. The number of PMAs, the expression of P-SEL, and integrin αIIbβ3 activation post-operatively was compared to pre-operative (or baseline) values and the fold-change was determined for each patient. (A) Circulating numbers of PMAs were significantly increased post-operatively in patients who developed VTE (+VTE, n = 13), compared to patients without VTE (−VTE, n = 19). In comparison, neither (B) P-SEL expression nor (C) integrin αIIbβ3 activation was associated with VTE. Data show the mean ± SEM for each group.