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. 2016 Jun 7;6:27489. doi: 10.1038/srep27489

Figure 1. The effect of Ms4022 on mycobacterial growth in response to anti-tuberculosis drug rifampin (RIF).

Figure 1

(A) Analysis of the structural characteristics of Ms4022. It contained a TetR_N superfamily domain within N domain. (B) Growth curves of the Ms/pMV261 and Ms/pMV261-Ms4022 were determined in the absence or presence of RIF. Ms/pMV261 and Ms/pMV261-Ms4022 were grown in 7H9 medium, which contains 30 μg/ml Kanamycin, without RIF (left panel) or 1.5 μg/ml RIF (right panel). (C) Ms/pMindD, ΔMs4022/pMindD and ΔMs4022/pMindD-Ms4022 were grown in 7H9 medium, which contains 30 μg/ml Kanamycin, with no drug (left panel) or 1.5 μg/ml RIF (right panel). For all these assays, aliquots were taken at the indicated times and the OD600 was measured. Each analysis was performed in triplicate, and standard errors were indicated as error bars.