Figure 1. Normal learning and basal glucose uptake in young PDAPP mice.

(a) Experimental design and training stage time points outlining our use of the training-to-criterion protocol. (b) PDAPP and WT mice (total n=127) learned to perform the visual cue task equally well (not significant). (c) Learning curves for sessions (Sess.) 1–3 of SRM training (days 15–17 in a) showed no significant difference between PDAPP and WT mice (ANOVA, between subjects comparison, F_1,92=2.78, P=0.10). (d) There was a small but significant difference in the number of Sess. of SRM training to reach criterion (t₉₂=1.84, P=0.035), associated with a trend suggesting overnight forgetting in PDAPP mice as shown in the within-Sess. escape latencies across Sess. 2 and 3 (groups × blocks: F_2,184=2.98, P=0.054). (e) The PDAPP mice did not differ in escape latency as they approached criterion (Sess. −2 to the Criterion Session (Criter. Sess.): between-groups comparison, F_1,92<1). (f) Basal glucose uptake (with no watermaze procedures) in 32 brain structures of young PDAPP and WT mice. No significant group differences were identified: between-subjects comparison, F<1; genotype × brain-region, F_3.4/100.5=1.40, P>0.10 Greenhouse-Geisser correction (Student's t-tests: P>0.05 for all individual brain structures). Means±1 s.e.m. Accumb., accumbens; Caud., caudate; Ctx, cortex; Dent., dentate; gen., geniculate; hipp., hippocampus; Hypothal., hypothalamus; ins., inserta; Lat., lateral; Mol. DG/LM, molecular dentate gyrus/lacunosum moleculare; Nu., nucleus; pall., pallidus; Periaq., periaquedactal; Postsubic., postsubiculum; Prel., prelimbic; put., putamen; Retrospl., retrosplenial; Somatos., somatosensory; subic., subiculum; Subthal., subthalamic; Sup. collic., superior colliculus; thal., thalamic.