Table 1. EC50s (nM) and Hill coefficients (shown in parentheses) of compounds binding to the base paired RNAs shown in Fig. 1.
Compound | AAUU | AUAU | GGCC | GCGC |
---|---|---|---|---|
1* | 170±10 (3.1±0.79) | 45±1 (1.5±0.32) | 390±20 (1.4±0.34) | 240±10 (0.92±0.34) |
2† | 170±40 (1.5±0.24) | 190±20 (1.6±0.28) | 8,550±250 (0.85±0.08) | 6,950±250 (0.77±0.16) |
AU-azide† | 45±6 (1.0±0.17) | 31±4 (1.0±0.13) | >6,000 | >2,000 |
*[Compound]=3 μM.
†[Compound]=1 μM.