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. 2015 Jun 16;29(4):1036–1044. doi: 10.1111/jvim.12835

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©2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Difference in weeks between comparisons of various methods for the analysis of serum creatinine (sCr), SDMA, and GFR for detecting initial decline in renal function in dogs affected with X‐linked hereditary nephropathy (n = 8). Age difference was calculated by subtracting the age at which a decrease in renal function was identified by method (2) from that identified by method (1). “(1) Better” indicates that method (1) detected a decline in renal function earlier than method (2); “(2) Better” indicates that method (2) detected this decline earlier than method (1). sCr cutoff: sCr ≥ 1.2 mg/dL; GFR cutoff: GFR <2 mL/min/kg; SDMA cutoff: SDMA≥14 μg/dL; sCr and SDMA trending refer to detection of a clinically relevant difference in the rate of change from prior values in an individual dog.