Table 1.
Significant variables (P < .05) in the univariate Cox's proportional hazard analysis for disease‐free period after transsphenoidal hypophysectomy. Variables with P > .05 are not included in this table
| Variable | HR | 95% CI | P‐Value | |
|---|---|---|---|---|
| P/B value | 22.664 | 4.478 | 114.712 | <.001 |
| ACTH2 | 1.008 | 1.002 | 1.014 | .007 |
| ACTH3 | 1.007 | 1.003 | 1.010 | <.001 |
| ACTH4 | 1.016 | 1.008 | 1.025 | <.001 |
| ACTH5 | 1.019 | 1.004 | 1.035 | .014 |
| Cort1 | 1.004 | 1.002 | 1.005 | <.001 |
| Cort2 | 1.004 | 1.002 | 1.005 | <.001 |
| Cort3 | 1.002 | 1.001 | 1.004 | <.001 |
| Cort4 | 1.004 | 1.003 | 1.006 | <.001 |
| normACTH2 | 4.477 | 1.416 | 14.152 | .011 |
| normACTH3 | 2.241 | 1.469 | 3.420 | <.001 |
| normACTH4 | 4.788 | 1.770 | 12.954 | .002 |
| normCort1 | 1.826 | 1.318 | 2.530 | <.001 |
| normCort2 | 1.888 | 1.286 | 2.772 | .001 |
| normCort3 | 1.498 | 1.176 | 1.908 | .001 |
| normCort4 | 2.067 | 1.407 | 3.035 | <.001 |
| RI ACTH | 1.011 | 1.003 | 1.018 | .005 |
| AUC Cort | 1.000 | 1.000 | 1.000 | <.001 |
| RI Cort | 1.005 | 1.003 | 1.008 | <.001 |
| RS Cort | 1.171 | 1.093 | 1.256 | <.001 |
AUC Cort, area under the curve for cortisol; CI, confidence interval; HR, hazard ratio; normACTH, normalized plasma ACTH concentration to preoperative value; normCort, normalized plasma cortisol concentration to preoperative value; P/B value, pituitary height/brain area value; RI, random intercept; RS, random slope.