Figure 4. Genes involved in the rough phenotype in the BY × 3S cross largely regulate signalling and transcriptional control by the Ras pathway.

A simplified portrait of the Ras pathway is presented. Components of the Ras pathway and other identified proteins are colour coded by whether they can result in the rough phenotype when mutated (red), harbour cryptic variants (green) or are unlikely to harbour functionally distinct alleles that affect colony morphology in the cross (black). IRA2 and SFL1 are coloured as both green and red because they fall into two of the aforementioned classes. Most of the genes that uncover the rough phenotype when mutated or possess cryptic variants function in Ras signalling and Ras-dependent transcriptional regulation. Certain proteins, namely End3, Mds3 and Trr1, do not act directly in the Ras pathway, but have been shown to either influence or be influenced by the Ras activity. Our results also suggest that Irc8 might have some functional relationship to the Ras pathway.