Table 2.
Bioequivalence data for reference and compounded itraconazole administered to 9 healthy Beagle dogs
| Subject | AUC (μg h/mL) | CMAX (μg/mL) | ||||||
|---|---|---|---|---|---|---|---|---|
| Reference | Compounded | Difference | Ratio (%) | Reference | Compounded | Difference | Ratio (%) | |
| Mean | 9.10 | 0.46 | −8.64 | 5.64 | 1.54 | 0.06 | −1.49 | 4.39 |
| SD | 4.53 | 0.34 | 4.48 | 3.55 | 1.02 | 0.08 | −0.94 | 7.91 |
| Range | 3.58–17.61 | 0–1.04 | −17.15 to −3.33 | 0–9.64 | 0.46–2.98 | 0–0.1 | −2.95 to −0.43 | 0–7.91 |
Difference, difference between the compounded and reference formulations; Ratio (%), ratio of the value for the compounded formulation to reference formulation expressed as a percent; SD, standard deviation.
Values were log‐transformed for comparisons.