Table 4.

Bioequivalence calculations for log‐transformed values of AUC and C_MAX for comparison of compounded and generic itraconazole to the reference formulation administered PO to 9 healthy Beagle dogs

Value	AUC		CMAX
	Compounded	Generic	Compounded	Generic
90% CIlower (%)	3.72	71.25	2.84	60.08
90% CIupper (%)	8.18	152.6	6.02	124.1a
Ratio (%)	5.52	104.2	4.13	86.34
Difference	−2.90	0.04	−3.19	−0.15
SE (+/−)	0.22	0.22	0.21	0.21
Power	0.24	0.25	0.25	0.26

CI, confidence interval; Difference, difference between the test (compounded or generic) and reference formulations; Ratio (%), ratio of the value for the test (compounded or generic) to reference formulation expressed as a percent; SE, standard error between formulations.

^aStatistically bioequivalent.