Table 1.
Baseline characteristics at inclusion (intention‐to‐treat population)
| Variable | Benazepril (n = 112) | Telmisartan (n = 112) | ||
|---|---|---|---|---|
| Mean (min–max) | No (%) | Mean (min–max) | No (%) | |
| Age (years) | 12.8 (2–22) | 13.6 (3–21) | ||
| Weight (kg) | 4.3 (2–11) | 4.4 (2–9) | ||
| Gender | ||||
| Female | 58 (51,8) | 55 (49.1) | ||
| Male | 54 (48,2) | 57 (50.9) | ||
| Neutered | 104 (92,9) | 106 (94.6) | ||
| Breed | ||||
| DLH | 6 (5.4) | 9 (8.0) | ||
| DSH | 72 (64.3) | 75 (67.0) | ||
| Mixed | 9 (8.0) | 4 (3.6) | ||
| Other | 20 (17.9) | 16 (14.3) | ||
| Persian | 5 (4.5) | 8 (7.1) | ||
| Serum Biochemistry | % >ULN | % >ULN | ||
| TT4 (μg/dL) | 1.9 (0.3–5.4) | 0.9 | 1.8 (0.3–4.3) | 0.0 |
| Creatinine (mg/dL)a | 2.4 (1.6–6.6) | 58 | 2.5 (1.1–6.6) | 64.3 |
| Urea (BUN) (mg/dL) | 48.7 (21.3–139.8) | 84.8 | 52.1 (23.3–299.4) | 79.5 |
| Sodium (mEq/L) | 154.9 (147.0–167.0) | 0.9 | 155.3 (147.6–174.0) | 1.8 |
| Potassium (mEql/L) | 4.5 (3.0–6.4) | 7.1 | 4.5 (3.0–8.1b) | 3.6 |
| Calcium (mg/dL) | 10.4 (7.6–13.2) | 6.3 | 10.4 (8.0–13.2) | 2.7 |
| Phosphate (mg/dL) | 5.0 (2.2–10.2) | 7.1 | 5.0 (2.2–15.8) | 6.3 |
| Albumin (mg/dL) | 3.4 (2.2–4.6) | 0.0 | 3.4 (2.6–4.5) | 0.0 |
| ALT (U/L) | 65.2 (22.0–210.8) | 1.8 | 65.1 (21.4–279.4) | 1.8 |
| ALP (U/L) | 32.8 (10.0–111.8) | 0.9 | 30.4 (12.0–129.0) | 0.9 |
| CBC | % <LLN, >ULN | %<LLN, >ULN | ||
| RBCc 10 × 12/L | 7.5 (3.4–10.9) | <3.6, >6.3 | 8.0 (3.9–14.6) | <2.7, >10.7 |
| HGB g/L | 108.2 (55–170) | <17.3, >1.2 | 113.4 (67–170) | <11.5, >2.6 |
| HCT % | 34.9 (19.0–54.0) | <10.8, >1.8 | 37.3 (21.0–69.8) | <5.4, >3.6 |
| WBCc g/L | 10.7 (1.9–28.9) | <17.1, >18.9 | 9.6 (2.8–49.2) | <17.0, >8.0 |
| Urine Variables | ||||
| Specific gravityc | 1.022 | 1.022 | ||
| UPC | 0.41 (0.1–2.2) | 0.41 (0.1–3.0) | ||
| Systolic BP (mmHg) | 147.7 (95–180) | 146.2 (98–176) | ||
| Amlodipine treatmentc | 6 (5.4) | 10 (8.9) | ||
| Kidney diet | 36 (32.1) | 39 (34.8) | ||
| Disease History | Mean Duration (years) | Mean Duration (years) | ||
| PU/PD | 0.66 | 63 (56.3) | 0.56 | 71 (63.4) |
| Decreased appetite | 0.41 | 28 (25.0) | 0.36 | 33 (29.5) |
| Weight loss | 0.53 | 48c (42.9) | 0.52 | 56 (50.0) |
| Palpably small kidneys | 21 (18.8) | 18 (16.1) | ||
a
Upper reference limit (ULN) laboratory 2.0 mg/dL.
b
Laboratory error suspected at D0, at recheck examinations potassium levels of this patient were well within reference ranges.
c
One missing value, LLN/ULN = lower/upper reference limit.