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. 2015 Dec 17;15(Suppl 1):154. doi: 10.1186/s12886-015-0137-5

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© Shirai and Saika. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Ocular surface mucins. The ocular surface epithelia express three MAMs, that are concentrated on the tips of the apical cells’ microplicae. Secreted mucins are produced by Goblet cells and secreted in the tear film. The loss of Muc16 activates Stat3 signaling in fibroblasts in the subconjunctival connective tissue and upregulates expression of cytokine. Reproduced from [67]