Table 8.
Sample size of the replication study needed for 6 diseases of WTCCC dataset when average power is estimated by EB based method. The Control-to-Case ratio of the replication study is set to 1. The significance levels used in the primary study and the replication study are α 1=5×10−8 and α 2=5×10−6, respectively
| 50 % | 60 % | 70 % | 80 % | 90 % | |
|---|---|---|---|---|---|
| Coronary artery disease | 4095 | 4784 | 5652 | 6885 | 9121 |
| Crohn’s disease | 4405 | 5252 | 6376 | 8092 | 11,552 |
| Hypertension | 5993 | 6992 | 8244 | 10,014 | 13,215 |
| Rheumatoid arthritis | 2666 | 3329 | 4147 | 5291 | 7357 |
| Type 1 diabetes | 2146 | 2640 | 3249 | 4094 | 5588 |
| Type 2 diabetes | 4027 | 4726 | 5633 | 6988 | 9721 |