Figure 8. Even PO distribution in a hyphal cell is an emergent consequence of opposing cytoskeletal forces.

MTs mix and distribute POs by supporting bidirectional EE motility that mediates anterograde (red arrow) and retrograde (green arrow) DT of POs, but also underlie their enhanced AD along the axis of the cell (yellow arrows). MT bending exerts lateral force (purple arrow) and increases the contact between POs and EEs. MT-based mechanisms oppose a slow pole-ward drift of POs (dark green arrow), which is mediated by myosin-5 at the cell periphery. Thermal diffusion plays only a minor role in PO mobility and is excluded from the diagram.