Figure 7. Wound-healing in chimaeric mice with normal or hyper-long telomeres.

(a) Scheme shows that the chimaeric mice analysed were constituted by two different backgrounds, 129S1 and C57Bl6. While C57Bl6 background contains cells of normal telomere length, the 129S1 cells contains cells with normal telomere length (from ES at passage 4) or cells bearing hyper-long telomeres (from ES cells at passage 16). (b) The graph shows the per cent of skin healed in chimaeric mice bearing normal or hyper-long telomeres and age-matched controls at 7 days after the wound on skin was performed. Wounds were made with a circular 4 mm razor blade and pictures were taken. Representative graph of two independent experiments. (c) Representative images of chimaeric mice (two coloured skin) and age-matched controls before and at day 7 after wounds were made. Photagraphs were taken every two days and wounds were measured using Image J software at day 0 (when wounds were performed) and at day 7. The s.e.m. was represented in error bars. Student t-test with the Bonferroni correction was used to calculate the P values.